USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: O00764 USC-OGP 2-DE database:  O00764 O00764 General information about the entry View entry in simple text format Entry name PDXK_HUMAN Primary accession number O00764 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Pyridoxal kinase; EC=2.7.1.35; AltName: Full=Pyridoxine kinase;. Gene name Name=PDXK Synonyms=C21orf124, C21orf97, PKH, PNK ORFNames=PRED79 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1218: pI=5.73; Mw=36260 Cross-references UniProtKB/Swiss-Prot O00764; PDXK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PDXK_HUMAN Primary accession number O00764 Secondary accession number(s) Q7Z2Y0 Q9BS02 Sequence was last modified on  July 1, 1997 (version 1) Annotations were last modified on  March 15, 2017 (version 168) Name and origin of the protein Description RecName: Full=Pyridoxal kinase; EC=2.7.1.35; AltName: Full=Pyridoxine kinase; Gene name Name=PDXK Synonyms=C21orf124, C21orf97, PKH, PNK ORFNames=PRED79 Encoded on Name=PDXK; Synonyms=C21orf124, C21orf97, PKH, PNK; ORFNames=PRED79 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U89606; AAC51233.1; -; mRNA EMBL AY303972; AAP73047.1; -; mRNA EMBL AP001752; BAA95540.1; -; Genomic_DNA EMBL BC000123; AAH00123.1; -; mRNA EMBL BC005825; AAH05825.1; -; mRNA CCDS CCDS13699.1; -. [O00764-1]; . RefSeq NP_003672.1; NM_003681.4. [O00764-1]; . RefSeq XP_005261256.1; XM_005261199.2. [O00764-3]; . RefSeq XP_011528062.1; XM_011529760.2. [O00764-3]; . RefSeq XP_011528063.1; XM_011529761.1. [O00764-3]; . RefSeq XP_016883972.1; XM_017028483.1. [O00764-3]; . RefSeq XP_016883973.1; XM_017028484.1. [O00764-3]; . UniGene Hs.284491; -; . PDB 2AJP; X-ray; 2.50 A; A/B=6-312 PDB 2F7K; X-ray; 2.80 A; A/B=1-312 PDB 2YXT; X-ray; 2.00 A; A/B=1-312 PDB 2YXU; X-ray; 2.20 A; A/B=1-312 PDB 3FHX; X-ray; 2.50 A; A/B=1-312 PDB 3FHY; X-ray; 2.30 A; A/B=1-312 PDB 3KEU; X-ray; 2.10 A; A/B=1-312 PDB 4EN4; X-ray; 2.15 A; A/B=1-312 PDB 4EOH; X-ray; 2.10 A; A/B=1-312 PDBsum 2AJP; -; . PDBsum 2F7K; -; . PDBsum 2YXT; -; . PDBsum 2YXU; -; . PDBsum 3FHX; -; . PDBsum 3FHY; -; . PDBsum 3KEU; -; . PDBsum 4EN4; -; . PDBsum 4EOH; -; . ProteinModelPortal O00764; -; . SMR O00764; -; . BioGrid 114135; 23; . IntAct O00764; 5; . MINT MINT-5002166; -; . STRING 9606.ENSP00000291565; -; . BindingDB O00764; -; . ChEMBL CHEMBL1075181; -; . DrugBank DB04776; (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol; . DrugBank DB00147; Pyridoxal; . DrugBank DB00165; Pyridoxine; . iPTMnet O00764; -; . PhosphoSitePlus O00764; -; . BioMuta PDXK; -; . REPRODUCTION-2DPAGE IPI00013004; -; . REPRODUCTION-2DPAGE O00764; -; . EPD O00764; -; . PaxDb O00764; -; . PeptideAtlas O00764; -; . PRIDE O00764; -; . DNASU 8566; -; . Ensembl ENST00000291565; ENSP00000291565; ENSG00000160209. [O00764-1]; . Ensembl ENST00000468090; ENSP00000418359; ENSG00000160209. [O00764-2]; . GeneID 8566; -; . KEGG hsa:8566; -; . UCSC uc002zdn.4; human. [O00764-1]; . CTD 8566; -; . DisGeNET 8566; -; . GeneCards PDXK; -; . HGNC HGNC:8819; PDXK; . HPA CAB033918; -; . HPA HPA030196; -; . HPA HPA030197; -; . HPA HPA030198; -; . MIM 179020; gene; . neXtProt NX_O00764; -; . OpenTargets ENSG00000160209; -; . PharmGKB PA33162; -; . eggNOG KOG2599; Eukaryota; . eggNOG COG2240; LUCA; . GeneTree ENSGT00390000003874; -; . HOGENOM HOG000258174; -; . HOVERGEN HBG000732; -; . InParanoid O00764; -; . KO K00868; -; . OMA VYQQKVV; -; . OrthoDB EOG091G0EKE; -; . PhylomeDB O00764; -; . TreeFam TF315004; -; . BioCyc MetaCyc:HS08466-MONOMER; -; . BRENDA 2.7.1.35; 2681; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-964975; Vitamins B6 activation to pyridoxal phosphate; . SABIO-RK O00764; -; . ChiTaRS PDXK; human; . EvolutionaryTrace O00764; -; . GeneWiki PDXK; -; . GenomeRNAi 8566; -; . PRO PR:O00764; -; . Proteomes UP000005640; Chromosome 21; . Bgee ENSG00000160209; -; . CleanEx HS_PDXK; -; . ExpressionAtlas O00764; baseline and differential; . Genevisible O00764; HS; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0035580; C:specific granule lumen; TAS:Reactome; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0031403; F:lithium ion binding; IDA:UniProtKB; . GO GO:0000287; F:magnesium ion binding; IDA:UniProtKB; . GO GO:0030955; F:potassium ion binding; IDA:UniProtKB; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0008478; F:pyridoxal kinase activity; IDA:UniProtKB; . GO GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB; . GO GO:0031402; F:sodium ion binding; IDA:UniProtKB; . GO GO:0008270; F:zinc ion binding; IDA:UniProtKB; . GO GO:0008283; P:cell proliferation; IDA:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0009443; P:pyridoxal 5'-phosphate salvage; IBA:GO_Central; . GO GO:0042823; P:pyridoxal phosphate biosynthetic process; IDA:UniProtKB; . GO GO:0042816; P:vitamin B6 metabolic process; IC:UniProtKB; . CDD cd01173; pyridoxal_pyridoxamine_kinase; 1; . Gene3D 3.40.1190.20; -; 1; . InterPro IPR013749; PM/HMP-P_kinase-1; . InterPro IPR004625; PyrdxlKinase; . InterPro IPR029056; Ribokinase-like; . PANTHER PTHR10534; PTHR10534; 1; . Pfam PF08543; Phos_pyr_kin; 1; . SUPFAM SSF53613; SSF53613; 1; . TIGRFAMs TIGR00687; pyridox_kin; 1; .

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